What is SCCOHT?



Small cell carcinoma of the ovary, hypercalcemic type (SCCOHT) is a rare and aggressive cancer which mainly occurs in adolescents and young women. It represents less than 0.01% of all ovarian malignancies , with fewer than 500 cases reported to date

Approximately two thirds of patients with ovarian small cell carcinoma have hypercalcemia.  Hypercalcemia is a condition in which the calcium level in your blood is above normal. The clinical management of SCCOHT has varied widely. Outcome remains poor, with estimated long-term survival reported as 33% in stage I disease, and 10–20% overall.

~500

Reported cases worldwide

<1%

Of all ovarian cancer diagnoses

10-20%

Overall survival rate

>95%

Of SCCOHT have SMARCA4 variant

Ovarian Symptoms

Persistent bloating / Increased abdominal size | Pelvic or abdominal pain.
Difficulty eating or feeling full quickly / weight loss | Urinary symptoms (urgency or frequency).
Fatigue | Indigestion | Back pain.
Constipation & menstrual irregularities.

Diagnosing SCCOHT

Pelvic/rectal exam.
CA125 blood test.
Transvaginal Ultrasound.
Pelvic Magnetic Resonance Imaging




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